期刊
CHEMISTRY-A EUROPEAN JOURNAL
卷 21, 期 25, 页码 9034-9038出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.201501089
关键词
carbon; imaging agents; positron emission tomography; radiopharmaceuticals; tanaproget
资金
- EPSRC [EP/L025140/1]
- Royal Society [RG110449]
- Imperial College-EPSRC Kick-Start programme
- EPSRC [EP/L025140/1] Funding Source: UKRI
- Cancer Research UK [16464] Funding Source: researchfish
- Engineering and Physical Sciences Research Council [EP/K503381/1, EP/L025140/1] Funding Source: researchfish
Herein a new C-11 radiolabelling strategy for the fast and efficient synthesis of thioureas and related derivatives using the novel synthon, (CS2)-C-11, is reported. This approach has enabled the facile labelling of a potent progesterone receptor (PR) agonist, [C-11]Tanaproget, by the intramolecular reaction of the acyclic aminohydroxyl precursor with (CS2)-C-11, which has potential applications as a positron emission tomography radioligand for cancer imaging.
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