期刊
PARKINSONISM & RELATED DISORDERS
卷 24, 期 -, 页码 56-62出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.parkreldis.2016.01.015
关键词
Parkinson's disease; Forced exercise; Aerobic exercise; fMRI
资金
- NIH [R21HD056316, RO1NS065198-01]
Introduction: Studies in animal models of Parkinson's disease (PD) have suggested that the rate of exercise performance is important in treatment efficacy and neuroprotection. In humans with PD, lower extremity forced-exercise (FE) produced global improvements in motor symptoms based on clinical ratings and biomechanical measures of upper extremity function. Methods: fMRI was used to compare the underlying changes in brain activity in PD patients following the administration of anti-parkinsonian medication and following a session of FE. Results: Nine individuals with PD completed fMRI scans under each condition: off anti-PD medication, on anti-PD medication, and off medication + FE. Unified Parkinson's Disease Rating Motor Scale scores improved by 50% in the FE condition compared to the off-medication condition. The pattern of fMRI activation after FE was similar to that seen with anti-PD medication. Direct comparison of the fMRI activation patterns showed high correlation between FE and anti-PD medication. Conclusion: These findings suggest that medication and FE likely utilize the same pathways to produce symptomatic relief in individuals with PD. (C) 2016 Elsevier Ltd. All rights reserved.
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