期刊
CHEMISTRY-A EUROPEAN JOURNAL
卷 22, 期 6, 页码 1900-1907出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.201503954
关键词
biocatalysis; amines; NADPH; stereoselectivity; oxidoreductases
资金
- Industrial Affiliates of the Centre of Excellence for Biocatalysis, Biotransformation and Biocatalytic Manufacture (CoEBio3)
- Biotechnology and Biological Sciences Research Council (BBSRC) [BB/M006832/1]
- Royal Society
- BBSRC [BB/M006832/1, BB/M006611/1] Funding Source: UKRI
Imine reductases (IREDs) are NADPH-dependent oxidoreductases that catalyse the asymmetric reduction of cyclic prochiral imines to amines, with excellent stereoselectivity. Since their discovery, stereocomplementary IREDs have been applied to the production of both (S) and (R) cyclic secondary amines, and the expansion in gene sequences recently identified has hinted at new substrate ranges that extend into acyclic imines and even suggest the possibility of asymmetric reductive amination from suitable ketone and amine precursors. Structural studies of various IREDs are beginning to reveal the complexities inherent in determining substrate range, stereoselectivity and mechanism in these enzymes, which represent a valuable emerging addition to the toolbox of available biocatalysts for chiral amine production.
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