期刊
PARKINSONISM & RELATED DISORDERS
卷 22, 期 -, 页码 74-79出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.parkreldis.2015.11.015
关键词
Parkinson's disease; Parkinson's disease with mild cognitive impairment; Olfaction; Awareness; Cognitive impairment
资金
- Ministry of Education, Science and Technology [24390278, 26860657]
- Japan Foundation for Neuroscience and Mental Health
- Grants-in-Aid for Scientific Research [24390219] Funding Source: KAKEN
Background: Hyposmia is a common non-motor symptom in Parkinson's disease (PD). However, patients with PD are sometimes unaware of their olfactory dysfunction, resulting in an under-diagnosis of this symptom. To determine whether the loss of awareness of hyposmia results from cognitive impairment in patients with PD, we investigated the relationship between the degree of hyposmia self-awareness and the cognitive status of non-demented PD patients. Methods: Thirty-one non-demented patients with PD and 20 healthy controls (HC) were assessed via a self-reported olfactory questionnaire and an odor identification test. PD patients were sub-classified as having mild cognitive impairment (PD-MCI) or as cognitively normal (PD-CN) (according to the current PD-MCI criteria). We compared the degree of hyposmia self-awareness between the PD-MCI and PD-CN groups. Results: The PD-MCI group scored the lowest on the odor identification test among all groups, whereas PD-MCI patients tended to rate their olfactory function higher on the self-reported olfactory questionnaire than PD-CN patients. Differences in the scores of subjective and objective olfactory measures between the PD-MCI and PD-CN groups were significant (p = 0.0069). Conclusions: The loss of awareness of hyposmia is closely associated with mild cognitive impairment (MCI) in PD patients. (C) 2015 Elsevier Ltd. All rights reserved.
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