期刊
PARASITES & VECTORS
卷 9, 期 -, 页码 -出版社
BIOMED CENTRAL LTD
DOI: 10.1186/s13071-016-1739-3
关键词
DENV; WNV; CHIKV; Arbovirus; Aedes; Ochlerotatus; Mosquito; Vector competence
资金
- Biotechnology and Biological Sciences Research Council
- National Institute of Health Research Health Protection Research Unit in Emerging and Zoonotic Infections
- National Institute for Health Research Health Protection Research Unit (NIHR HPRU) in Emerging and Zoonotic Infections at the University of Liverpool
- Public Health England (PHE)
- Liverpool School of Tropical Medicine (LSTM)
- Biotechnology and Biological Sciences Research Council [BB/K018507/1, BB/F021933/1] Funding Source: researchfish
- National Institute for Health Research [RP-PG-0108-10048, NF-SI-0514-10177, IS-HPU-1112-10117] Funding Source: researchfish
- BBSRC [BB/F021933/1, BB/K018507/1] Funding Source: UKRI
Background: To date there has been no evidence of mosquito-borne virus transmission of public health concern in the UK, despite the occurrence of more than 30 species of mosquito, including putative vectors of arboviruses. The saltmarsh mosquito Ochlerotatus detritus [syn. Aedes (Ochlerotatus) detritus] is locally common in parts of the UK where it can be a voracious feeder on people. Methods: Here, we assess the competence of O. detritus for three major arboviruses: dengue virus (DENV), chikungunya virus (CHIKV) and West Nile virus (WNV) using adult mosquitoes reared from wild, field-obtained immatures. Results: We demonstrate laboratory competence for WNV at 21 degrees C, with viral RNA detected in the mosquito's saliva 17 days after oral inoculation. By contrast, there was no evidence of laboratory competence of O. detritus for either DENV or CHIKV. Conclusions: To our knowledge, this is the first study to demonstrate competence of a UK mosquito for WNV and confirms that O. detritus may present a potential risk for arbovirus transmission in the UK and that further investigation of its vector role in the wild is required.
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