期刊
CHEMISTRY-A EUROPEAN JOURNAL
卷 22, 期 4, 页码 1406-1414出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.201503931
关键词
(+)-polyaniline; microcrystals; photoelectron spectroscopy; principal-component analysis; receptors
资金
- Ministry of Science and Technology of Taiwan, ROC [MOST 102-2221-E-008-071-MY2, 104-2221-E-008-070-MY3]
The adsorption of phenylaniline (Phe) enantiomers on (+)-polyaniline (PAN)-chelated [In(OH)(bdc)](n) microcrystals was carefully designed and studied by using the Job titration, circular dichroism, X-ray photoelectron spectroscopy, and photoluminescence to mimic heterotrimeric guanine nucleotide-binding protein (G protein)-coupled receptors in selective, but not specific, ligand binding with chiral recognition and signal transduction. Six essential working principles across different length scales are unraveled: 1) a chiral (+)-PAN (host), 2) specific sites for Phe-(+)/PAN (guest-host) binding, 3) a conformational change of (+)-PAN after binding with Phe enantiomers, 4) different degrees of packing for (+)-PAN, 5) interactions between (+)-PAN and the underlying signal-generating framework (i.e., [In(OH)(bdc)](n) microcrystals), and 6) a systematic photoluminescent signal combination by using principal-component analysis from the other three polymer-chelated metal-organic frameworkds (MOFs), such as poly(acrylic acid) (PAA), sodium alginate (SA), and polyvinylpyrrolidone (PVP) to enhance the selectivity and discrimination capabilities.
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