A Novel Pd-Catalysed Annulation Reaction for the Syntheses of Pyrroloindoles and Pyrroloquinolines

Pd-catalysed annulation reactions between indole derivatives and internal alkyne esters leading to various pyrrolo[1,2-a]indoles and pyrroloquinolines have been developed. The strategy involves an intermolecular addition of the indole nitrogen on to the internal alkyne ester followed by an intramolecular insertion of a vinyl-palladium complex into the carbonyl group. This method offers a facile and practical approach to pyrrolo[1,2-a] indoles and pyrroloquinolines.