期刊
CHEMISTRY-A EUROPEAN JOURNAL
卷 21, 期 22, 页码 8043-8046出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.201500534
关键词
asymmetric catalysis; hydrogen transfer; ketone reduction; organometallic complexes; osmium
资金
- ERC [247450]
- EPSRC [EP/F034210/1]
- WCPRS
- Bruker Daltonics
- Leverhulme Trust [RGP 374]
- Engineering and Physical Sciences Research Council [EP/F034210/1] Funding Source: researchfish
- EPSRC [EP/F034210/1] Funding Source: UKRI
Asymmetric transfer hydrogenation (ATH) is an important process in organic synthesis for which the Noyori-type Ru-II catalysts [(arene)Ru(Tsdiamine)] are now well established and widely used. We now demonstrate for the first time the catalytic activity of the osmium analogues. X-ray crystal structures of the 16-electron Os-II catalysts are almost identical to those of Ru-II. Intriguingly the precursor complex was isolated as a dichlorido complex with a monodentate amine ligand. The Os-II catalysts are readily synthesised (within 1h) and exhibit excellent enantioselectivity in ATH reactions of ketones.
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