期刊
CHEMISTRY-A EUROPEAN JOURNAL
卷 21, 期 12, 页码 4580-4584出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.201406305
关键词
arylation; domino reactions; nitrogen heterocycles; palladium; sulfones
资金
- Spanish MINECO-FEDER [CTQ2012-31391]
A new strategy for the synthesis of tetrahydroisoquinolines based on the Pd-0-catalyzed intramolecular -arylation of sulfones is reported. The combination of this Pd-catalyzed reaction with intermolecular Michael and aza-Michael reactions allows the development of two- and three-step domino processes to synthesize diversely functionalized scaffolds from readily available starting materials.
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