期刊
CHEMISTRY-A EUROPEAN JOURNAL
卷 21, 期 52, 页码 18915-18920出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.201503791
关键词
alkynylation; fluorescence; iodonium; olefination; regioselectivity
资金
- Guangdong Department of Science and Technology [2013B051000034, 2014A030313196]
- Guangzhou Innovation Research Program [LCY201317]
- National Basic Research Program of China [2012CB967004]
Although cyclic diaryliodonium species have the potential to act as valuable synthons for cascade transformations, they still remain largely unexplored. The regioselectivity associated with unsymmetrical cyclic diaryliodonium species has previously been known to pose a challenge. A regioselective relayed alkynylation and olefination of unsymmetrical cyclic diaryliodonium species has been achieved by installation of a directing amido group. These relayed transformations were delayed until an oxazole ring had formed, delivering a series of unique fluorescent benzoxazoles. Moreover, some of these synthetic benzoxazoles showed apparent inhibitory activity against malignant cancer cells. Further confocal visualization revealed that benzoxazoles targeted cell nuclei. These findings might provide a novel structural scaffold to develop desirable anticancer agents.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据