期刊
OSTEOARTHRITIS AND CARTILAGE
卷 24, 期 7, 页码 1126-1134出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.joca.2016.01.984
关键词
Osteoarthritis; Cartilage imaging; Weight loss; Magnetic resonance imaging; T2 relaxation time
资金
- Osteoarthritis Initiative, a public-private partnership comprising five NIH contracts (National Institute of Arthritis and Musculoskeletal and Skin Diseases) [N01-AR-2-2258, N01-AR-2-2259, N01-AR-2-2260, N01-AR-2-2261, N01-AR-2-2262]
- NIH (National Institute of Arthritis and Musculoskeletal and Skin Diseases) [R01AR064771, P50-AR060752]
- Merck Research
- Novartis Pharmaceuticals
- GlaxoSmithKline
- Pfizer
- Foundation for the National Institutes of Health
Objective: To investigate compositional cartilage changes measured with 3T MRI-based T2 values over 48 months in overweight and obese individuals with different degrees of weight loss (WL) and to study whether WL slows knee cartilage degeneration and symptom worsening. Design: We studied participants from the Osteoarthritis Initiative with risk factors or radiographic evidence of mild to moderate knee osteoarthritis with a baseline BMI >= 25 kg/m(2). We selected subjects who over 48 months lost a, moderate (BMI change, 5-10% WL, n = 180) or large amount of weight (>= 10% WL, n = 78) and frequency-matched these to individuals with stable weight (< 3%, n = 258). Right knee cartilage T2 maps of all compartments and grey-level co-occurrence matrix (GLCM) texture analyses were evaluated and associations with WL and clinical symptoms (WOMAC subscales for pain, stiffness and disability) were assessed using multivariable regression models. Results: The amount of weight change was significantly associated with change in cartilage T2 of the medial tibia (beta 0.9 ms, 95% CI 0.4 to 1.1, P = 0.001). Increase of T2 in the medial tibia was significantly associated with increase in WOMAC pain (b 0.5 ms, 95% CI 0.2 to 0.6, P = 0.02) and disability (beta 0.03 ms, 95% CI 0.003 to 0.05, P = 0.03). GLCM contrast and variance over all compartments showed significantly less progression in the > 10% WL group compared to the stable weight group (both comparisons, P = 0.04). Conclusions: WL over 48 months is associated with slowed knee cartilage degeneration and improved knee symptoms. (C) 2016 Osteoarthritis Research Society International. Published by Elsevier Ltd. All rights reserved.
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