期刊
OSTEOARTHRITIS AND CARTILAGE
卷 24, 期 8, 页码 1317-1329出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.joca.2016.03.010
关键词
Knee injury; Knee osteoarthritis; KOOS; Patient-reported outcome measures; Measurement properties; Meta-analysis
资金
- National Health and Medical Research Council (Australia) [628918]
- UQ Postdoctoral Research Fellowship
- Oak Foundation
- Swedish Medical Research Council
Objective: To conduct a systematic review and meta-analysis to synthesize evidence regarding measurement properties of the Knee injury and Osteoarthritis Outcome Score (KOOS). Design: A comprehensive literature search identified 37 eligible papers evaluating KOOS measurement properties in participants with knee injuries and/or osteoarthritis (OA). Methodological quality was evaluated using the COSMIN checklist. Where possible, meta-analysis of extracted data was conducted for all studies and stratified by age and knee condition; otherwise narrative synthesis was performed. Results: KOOS has adequate internal consistency, test-retest reliability and construct validity in young and old adults with knee injuries and/or OA. The ADL subscale has better content validity for older patients and Sport/Rec for younger patients with knee injuries, while the Pain subscale is more relevant for painful knee conditions. The five-factor structure of the original KOOS is unclear. There is some evidence that the KOOS subscales demonstrate sufficient unidimensionality, but this requires confirmation. Although measurement error requires further evaluation, the minimal detectable change for KOOS subscales ranges from 14.3 to 19.6 for younger individuals, and >= 20 for older individuals. Evidence of responsiveness comes from larger effect sizes following surgical (especially total knee replacement) than non-surgical interventions. Conclusions: KOOS demonstrates adequate content validity, internal consistency, test-retest reliability, construct validity and responsiveness for age-and condition-relevant subscales. Structural validity, cross-cultural validity and measurement error require further evaluation, as well as construct validity of KOOS Physical function Short form. Suggested order of subscales for different knee conditions can be applied in hierarchical testing of endpoints in clinical trials. (C) 2016 Osteoarthritis Research Society International. Published by Elsevier Ltd. All rights reserved.
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