期刊
CHEMISTRY-A EUROPEAN JOURNAL
卷 21, 期 50, 页码 18301-18308出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.201503414
关键词
cross-coupling; enol ethers; indium; silicon; silyl ketene imines
资金
- Ministry of Education, Culture, Sports, Science, and Technology (Japan)
- Tonen General Sekiyu Research and Development Encouragement Foundation
- Tokuyama Science Foundation
- Frontier Research Base for Global Young Researchers, Osaka University, on the Program of MEXT
- Grants-in-Aid for Scientific Research [25105735, 15H05848, 26810059] Funding Source: KAKEN
Herein, a coupling reaction of enol ethers with silyl ketene imines in the presence of catalytic amounts of InBr3 and Me3SiBr is described. Kinetic studies have revealed that an indium catalyst and Me3SiBr accelerated the coupling process and the regeneration of the catalyst, respectively. Various types of enol ethers and silyl ketene imines are applicable. In addition, a formal synthesis of verapamil was achieved by using this novel coupling reaction.
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