期刊
CHEMISTRY-A EUROPEAN JOURNAL
卷 21, 期 49, 页码 17870-17876出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.201503303
关键词
azobenzene; DNA; nucleic acids; photochemistry; photoswitches
资金
- Deutsche Forschungsgemeinschaft (DFG) [SFB 902]
- Cluster of Excellence Macromolecular Complexes [EXC 115]
- Ministry of Education, Culture, Sports, Science and Technology, Japan [24750173, 25248037, 24104005]
- Grants-in-Aid for Scientific Research [25248037, 24750173, 24104005] Funding Source: KAKEN
Herein, we report the reversible light-regulated destabilization of DNA duplexes by using azobenzene C-nucleoside photoswitches. The incorporation of two different azobenzene residues into DNA and their photoswitching properties are described. These new residues demonstrate a photoinduced destabilization effect comparable to the widely applied D-threoninol-linked azobenzene switch, which is currently the benchmark. The photoswitches presented herein show excellent photoswitching efficiencies in DNA duplexes - even at room temperature - which are superior to commonly used azobenzene-based nucleic acid photoswitches. In addition, these photoswitching residues exhibit high thermal stability and excellent fatigue resistance, thus rendering them one of the most efficient candidates for the regulation of duplex stability with light.
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