期刊
CHEMISTRY-A EUROPEAN JOURNAL
卷 21, 期 28, 页码 9998-10002出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.201501806
关键词
asymmetric cyclizations; dipeptides; Michael addition; organocatalysis; quaternary phosphoniums
资金
- National Basic Research Program of China (973 Program) [2010CB833200]
- National Natural Science Foundation of China [21272247, 21290184]
A novel family of dipeptide-based multifunctional quaternary phosphonium salts has been developed as chiral phase-transfer catalysts, which feature ready accessibility and structure modularity, allowing easy fine-tunings of activity. They demonstrated high efficiency in catalyzing the tandem asymmetric Michael addition/intramolecular S(N)2 reaction between 6 or 7-substituted conjugate enones and malonates, providing synthetically important five or six-membered carbocycles and heterocycles in good yields and with good to excellent enantioselectivities.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据