期刊
CHEMISTRY-A EUROPEAN JOURNAL
卷 21, 期 30, 页码 10616-10628出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.201500831
关键词
carbohydrate chemistry; chemical glycobiology; glycodiagnostics; glycomimetics; therapeutic glycoproteins; vaccines
资金
- European Commission
- Spanish Ministry of Economy and Competitiveness, MINECO [CTQ2012-32025]
Glycans are everywhere in biological systems, being involved in many cellular events with important implications for medical purposes. Building upon a detailed understanding of the functional roles of carbohydrates in molecular recognition processes and disease states, glycans are increasingly being considered as key players in pharmacological research. On the basis of the important progress recently made in glycochemistry, glycobiology, and glycomedicine, we provide a complete overview of successful applications and future perspectives of carbohydrates in the biopharmaceutical and medical fields. This review highlights the development of carbohydrate-based diagnostics, exemplified by glycan imaging techniques and microarray platforms, synthetic oligosaccharide vaccines against infectious diseases (e.g., HIV) and cancer, and finally carbohydrate-derived therapeutics, including glycomimetic drugs and glycoproteins.
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