期刊
ORIGINS OF LIFE AND EVOLUTION OF BIOSPHERES
卷 47, 期 4, 页码 481-497出版社
SPRINGER
DOI: 10.1007/s11084-016-9526-x
关键词
Autocatalysis; Ecosystem selection; Life-like chemistry; Neighborhood selection; Prebiotic chemistry; Self-propagation; Surface catalysis
类别
资金
- Wisconsin Alumni Research Foundation via the University of Wisconsin-Madison Graduate School
- National Science Foundation [CHE-1624562]
- Direct For Mathematical & Physical Scien
- Division Of Chemistry [1624562] Funding Source: National Science Foundation
Most experimental work on the origin of life has focused on either characterizing the chemical synthesis of particular biochemicals and their precursors or on designing simple chemical systems that manifest life-like properties such as self-propagation or adaptive evolution. Here we propose a new class of experiments, analogous to artificial ecosystem selection, where we select for spontaneously forming self-propagating chemical assemblages in the lab and then seek evidence of a response to that selection as a key indicator that life-like chemical systems have arisen. Since surfaces and surface metabolism likely played an important role in the origin of life, a key experimental challenge is to find conditions that foster nucleation and spread of chemical consortia on surfaces. We propose high-throughput screening of a diverse set of conditions in order to identify combinations of food, energy sources, and mineral surfaces that foster the emergence of surface-associated chemical consortia that are capable of adaptive evolution. Identification of such systems would greatly advance our understanding of the emergence of self-propagating entities and the onset of adaptive evolution during the origin of life.
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