Synthesis of Ferrocene-Based Pyridinones through Rh(III)-Catalyzed Direct C-H Functionalization Reaction

Synthesis of ferrocene-based pyridinones via Rh(III)-catalyzed annulation of ferrocenecarboxamides with internal alkynes has been developed using a directing group as the internal oxidant. This method displays good functional group tolerance and delivers ferrocene-based pyridinones generally in moderate to good yields. Additionally, an asymmetric reaction can be achieved in the presence of a chiral catalyst Rh1.