期刊
ORGANIC PROCESS RESEARCH & DEVELOPMENT
卷 20, 期 6, 页码 1104-1107出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.oprd.6b00133
关键词
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A general selective and environmentally friendly method for the formation of amide bonds using a surfactant in water as medium is described. The use of readily available 1-ethy1-3-(3-(dimethylamino)propyl)-carbodiimide (EDC) and hydroxybenzotriazol (HOBt) as a coupling system, N-methylmorpholine (NMM), and TPGS-750-M represents mild conditions allowing for chemoselective amidation of unprotected amino alcohols. Comparative results with classical polar aprotic solvents such as dimethylformamide or acetonitrile are presented.
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