期刊
ORGANIC LETTERS
卷 18, 期 13, 页码 3250-3253出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.6b01500
关键词
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资金
- FCT [SFRH/BD/89518/2012]
- Associated Laboratory for Sustainable Chemistry- Clean Processes and Technologies-LAQV - national funds from FCT/MEC [UID/QUI/50006/2013]
- ERDF [POCI-01-0145-FEDER-007265]
- Fundacao para a Ciencia e Tecnologia [RECI/BBB-BQB/0230/2012]
- Fundação para a Ciência e a Tecnologia [SFRH/BD/89518/2012] Funding Source: FCT
A practical palladium-catalyzed cascade C-N cross-coupling/Heck reaction of alkenyl bromides with, amino-o-bromopyridines is described for a straightforward synthesis of substituted 4-, 5-, 6-, and 7-azaindoles using a Pd-2(dba)(3)/XPhos/t-BuONa system. This procedure consists of the first cascade C-N cross-coupling/Heck approach toward all four azaindole isomers from available aminopyridines. The scope of the reaction was investigated and several alkenyl bromides were used, allowing access to different substituted azaindoles. This protocol was further explored for N-substituted amino-o-bromopyridines.
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