期刊
ORGANIC LETTERS
卷 18, 期 23, 页码 6026-6029出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.6b02960
关键词
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资金
- National Natural Science Foundation of China [21572096, 21302088]
- Shenzhen overseas high level talents innovation plan of technical innovation project [KQCX20150331101823702]
- Shenzhen special funds for the development of biomedicine, Internet, new energy, and new mate-rial industries [JCYJ20150430160022517]
- 100-Talent Program
- 131-Excellent Talent Plan in Shanxi Province
- Taiyuan University of Science and Technology of China
A catalytic radical protocol for 1,2-cyanofunctionalization of unactivated alkenes involving remote cyano migration triggered by addition of diverse carbon- and heteroatom-centered radicals to alkenes has been developed. This powerful strategy provides a diverse platform for the collection of a variety of synthetically important beta-functionalized alkyl nitriles bearing densely functionalized carbonyl, cyano, and other various functional groups within the same molecules. The substrates TMS (trimethylsilyl)-protected alkenyl cyanohydrins are straightforwardly accessible via simple cyanosilylation of the corresponding ketones.
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