期刊
ORGANIC LETTERS
卷 18, 期 21, 页码 5620-5623出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.6b02848
关键词
-
资金
- Union University
- NIH [1S10RR1028859]
Rh-catalyzed, chelation-induced, C-5 regioselective C-H functionalization of 8-amidoquinolines with a range of N-Boc aminals is reported for the first time. The addition of in situ generated imines to C(sp(2))-H bonds afforded branched amines in good to excellent yields. Moreover, this transformation features good functional group compatibility, broad substrate scope, and mild reaction conditions and is suitable for gram-scale synthesis. In addition, an unprecedented, chelation-induced, site-selective, remote dimerization of quinolines led to the formation of dimer frameworks in moderate yields under Rh-catalyzed conditions.
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