期刊
ORGANIC LETTERS
卷 18, 期 20, 页码 5412-5415出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.6b02814
关键词
-
资金
- National Natural Science Foundation of China [21425415, 21274058]
- National Basic Research Program of China [2015CB856303]
Despite their tremendous synthetic and pharmaceutical utility, primary azaaromatic amines remain elusive for access based on a generally applicable C-H functionalization strategy. An oxadiazolone-enabled approach is reported for convenient entry into N-Auisubstituted 1-aminoisoquinolines through Co (III)-catalyzed redox-neutral, step-, atom-, and purification-economic C-H functionalization with alkynes. A N-15 labeling experiment reveals the effectiveness of both oxadiazolone N atoms as directing sites. The installed primary amine can be harnessed as a synthetically useful handle for attachment of divergent appendages.
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