期刊
ORGANIC LETTERS
卷 18, 期 23, 页码 6086-6089出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.6b03075
关键词
-
资金
- National Natural Science Foundation of China [21332003, 21402051]
An enantioselective method for the synthesis of alpha-mercapto-beta-amino esters has been developed via a rhodium(II)/chiral phosphoric acid-cocatalyzed three-component reaction of diazo compounds, thiols, and imines. This transformation is proposed to proceed through enantioselective trapping of the sulfonium ylide intermediate generated in situ from the diazo compound and thiol by the phosphoric acid-activated imine. With this method, a series of alpha-mercapto-beta-amino esters were obtained in good yields with moderate to good stereoselectivities.
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