4.8 Article

Effects of Co-solvents on Reactions Run under Micellar Catalysis Conditions

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ORGANIC LETTERS
卷 19, 期 1, 页码 194-197

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AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.6b03468

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  1. NSF [GOALI SusChEM 1566212]
  2. Novartis

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The impact of varying percentages of an organic solvent added to reactions run in aqueous nanomicelles as the reaction Medium has been investigated. Issues such as: fates of reaction, percent conversion, and yield, as well as various practical aspects (e.g., effect on stirring, etc), are discussed, leading to an operationally simple method for the general improvement of potentially problematic systems across abroad range of reaction types, in particular for reactions run at scale.

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