4.8 Article

Copper-Catalyzed Intermolecular Chloro- and Bromotrifluoromethylation of Alkenes

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ORGANIC LETTERS
卷 18, 期 3, 页码 348-351

出版社

AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.5b03080

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资金

  1. National Natural Science Foundation of China [21402144, 21372181, 21572168]
  2. Fundamental Research Funds for the Central Universities [2042014kf0030]
  3. Innovation Seed Fund of Wuhan University School of Medicine

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A highly practical copper-catalyzed intermolecular halotrifluoromethylation of alkenes has been developed under mild reaction conditions. A variety of Cl/Br-containing trifluoromethyl derivatives were directly synthesized from a wide range of alkenes, including electron-deficient and unactivated alkenes.

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