期刊
ORGANIC LETTERS
卷 18, 期 9, 页码 2008-2011出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.6b00614
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资金
- San Francisco State University College of Science and Engineering
A concise, eight-step total synthesis of (-)-indolactam V, a nanomolar agonist of protein kinase C, is reported. The synthesis relies upon an efficient copper catalyzed amino acid arylation to establish the indole C4-nitrogen bond. This cross-coupling method is applicable to a range of hydrophobic amino acids, providing a platform for further diversification of indolactam alkaloid scaffolds and studies on their potent biological activity.
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