4.8 Article

Synthesis of a Water-Soluble Carboxylatobiphen[4]arene and Its Selective Complexation toward Acetylcholine

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ORGANIC LETTERS
卷 18, 期 21, 页码 5740-5743

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AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.6b03005

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  1. NNSFC [21472122, 21272147, 81202465, 81573354]
  2. National Key Technologies R&D Program for New Drugs of China [2012ZX09301003]
  3. Shanghai Pujiang Program [16PJD024]
  4. State Key Laboratory of Applied Organic Chemistry (Lanzhou University)

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The first water-soluble biphen[4]arene containing eight carboxylato moieties (carboxylatobiphen[4]arene, CBP4) has been synthesized. Selective molecular recognition of acetylcholine (ACh) against choline (Ch) and betaine (Bt) and pH-responsive host-guest complexation in aqueous media are described.

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