期刊
ORGANIC LETTERS
卷 18, 期 24, 页码 6468-6471出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.6b03365
关键词
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资金
- Natural Sciences and Engineering Research Council of Canada
- Fonds de recherche du Quebec-Nature et technologies
- OmegaChem
- Universite Laval
The direct esterification of carboxylic acids with perfluorinated alcohols mediated by XtalFluor-E is reported. The corresponding polyfluorinated esters are obtained in moderate to excellent yields with a broad range of carboxylic acids, including aromatic, heteroaromatic, aliphatic, and nonracemic chiral substrates, using only a slight excess (2 equiv) of the perfluorinated alcohol. Control experiments indicate that the reaction does not proceed through the formation of an acyl fluoride but most likely through a (diethylamino)difluoro-lambda(4)-sulfanyl carboxylate intermediate.
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