Copper-Catalyzed Intermolecular Hydroamination of Internal Alkynes with Anilines and Amines

The copper-catalyzed regioselective intermolecular hydroamination of the aryl and trifluoromethyl group or electron-withdrawing group substituted internal alkynes with amines has been accomplished. The reaction was effectively catalyzed by the ligand-free Cu(OTf)(2) and afforded the intended amine derivatives in good yields after treatment of NaBH3CN.