期刊
ORGANIC LETTERS
卷 18, 期 3, 页码 572-575出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.5b03609
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资金
- NSF of China [31170084]
- MOST of China [973:2012CB721000]
- Science and Technology Commission of Shanghai Municipality [15JC1400401]
- State Key Laboratory of Microbial Technology Open Projects Fund [M2015-08]
- Leopoldina Fellowship Program (German National Academy of Sciences Leopoldina, LPDS)
Heterologous expression of bacterial artificial chromosome (BAC) clones from the genomic library of Streptomyces variabilis Snt24 in Streptomyces lividans SBT5 which carried a truncated undecylprodigiosin biosynthetic gene cluster led to the identification of hybrubins A-C. The hybrubins represent a new carbon skeleton in which a tetramic acid moiety is fused to a 2,2'-dipyrrole building block. Gene knockout experiments confirmed that hybrubins are derived from two convergent biosynthetic pathways including the remaining genomic red genes of S. lividans SBT5 as well as the BAC encoded hbn genes for the production of 5-ethylidenetetramic acid. A possible biosynthetic pathway was also proposed.
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