期刊
ORGANIC LETTERS
卷 18, 期 11, 页码 2596-2599出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.6b00979
关键词
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资金
- National Science Foundation from the Antarctic Organisms and Ecosystems program [ANT-0838773, PLR-1341333, ANT-08328776, PLR-1341339]
- National Institutes of Health grants [AI103715, AI80626]
- Center of Excellence award from the State of Florida
- University of Alabama at Birmingham
- Directorate For Geosciences
- Office of Polar Programs (OPP) [1341339] Funding Source: National Science Foundation
- Directorate For Geosciences
- Office of Polar Programs (OPP) [1341333] Funding Source: National Science Foundation
A new rearranged spongian diterpene, darwinolide, has been isolated from the Antarctic Dendroceratid sponge Dendrilla membranosa. Characterized on the basis of spectroscopic and crystallographic analysis, the central seven-membered ring is hypothesized to originate from a ring expansion of a spongian precursor. Darwinolide displays 4-fold selectivity against the biofilm phase of methicillin-resistant Staphylococcus aureus compared to the planktonic phase and may provide a scaffold for the development of therapeutics for this difficult to treat infection.
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