期刊
ORGANIC LETTERS
卷 18, 期 24, 页码 6488-6491出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.6b03394
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资金
- Natural Sciences and Engineering Research Council (NSERC)
- University of Toronto
- Alphora Research, Inc.
- NSERC
- Ludwig-Maximilians-Universitat Munchen - Deutscher Akademischer Austauschdienst (DAAD)
- State of Bavaria
A palladium-catalyzed alpha-arylation of cyclic vinylogous esters to form products that are converted in one step to gamma-alkyl-gamma-aryl-substituted cyclohexenones is reported. This Pd-catalyzed reaction proceeds at room temperature, is generally high-yielding, and uses an amount of a commercially available catalyst as low as 0.25 mol %. The scope of aryl bromides is particularly broad, and alkenyl bromides can also be used. This two-step protocol, comprising alpha-arylation and reductive transposition, can be performed in one pot and is applicable to gram-scale synthesis.
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