4.8 Article

Palladium-Catalyzed Cascade Arene/Alkyne Annulation: Synthesis of Fluorene-Benzoxazine Derivatives

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ORGANIC LETTERS
卷 18, 期 19, 页码 4810-4813

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AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.6b02224

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资金

  1. Natural Science Foundation of China [21372174, 21542015]
  2. PAPD
  3. Major Basic Research Project of the Natural Science Foundation of the Jiangsu Higher Education Institutions [16KJA150002]
  4. Soochow University

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A palladium-catalyzed cascade arene/alkyne annulatiodreaction for the synthesis of fluorene-benzoxazine derivatives is developed. This transformation involves a 6-exo-dig cyclization, a 1,3-oxazine vinylpalladium intermediate, and a C-H bond activation.

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