期刊
ORGANIC LETTERS
卷 18, 期 19, 页码 4970-4973出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.6b02432
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资金
- NIH [GM09025901]
- NSF [CHE-1565788]
- Direct For Mathematical & Physical Scien
- Division Of Chemistry [1565788] Funding Source: National Science Foundation
A de novo asymmetric total synthesis of the macrolide natural product (S)-phoracantholide J has been achieved in 10 steps from the commodity chemicals (1-pentyne, ethyl acrylate, acetaldehyde, and hydrogen). The asymmetry of the route was introduced by a Noyori reduction of a 3-yn-2-one, which makes the route equally amenable to the synthesis of either enantiomer. In addition, this route relies upon an alkyne zipper, a hydroalkynylation, and a macrolactonization to complete the synthesis.
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