期刊
ORGANIC LETTERS
卷 18, 期 24, 页码 6396-6399出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.6b03293
关键词
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资金
- Erasmus Mundus Scholarship
- NIH [1R01GM097082-01]
- Innovative Medicines Initiative [115489]
- European Union under MSC ITN Accelerated Early stage drug dIScovery (AEGIS) Grant [675555]
- Marie Curie Actions (MSCA) [675555] Funding Source: Marie Curie Actions (MSCA)
The Passerini multicomponent reaction (P-3CR) toward the one-step synthesis of alpha-aminoxy-amide, by employing for the first time a N-hydroxamic acid component, has been reported. The sonication-accelerated, catalyst-free, simple, fast, and highly efficient Passerini reaction is used for the synthesis of diverse alpha-aminoxy-amides. The reaction is compatible with a vast range of aldehydes, isocyanides, and N-hydroxamic acids such as N-hydroxysuccinimides and phthalimides. The generated Passerini products can be easily converted into several follow-up products.
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