Copper-Catalyzed Direct Propargylation of Polyfluoroarenes with Secondary Propargyl Phosphates

A copper-catalyzed direct propargylation of polyfluoroarenes with secondary propargyl phosphates has been developed. The reaction proceeds under mild reaction conditions with high efficiency and regioselectivity and provides a concise and straightforward method for the synthesis of polyfluoroarylated derivatives of interest in both life and materials science.