期刊
CHEMISTRY-A EUROPEAN JOURNAL
卷 21, 期 34, 页码 11961-11965出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.201502414
关键词
convergent synthesis; information-containing macromolecules; iterative chemistry; sequence-controlled polymers; soluble supports
资金
- European Research Council under European Union/ERC [258593]
- ERC
- CNRS
- excellence network Chemistry of Complex Systems (LabEx CSC)
A simplified strategy for preparing non-natural information-containing polymers is reported. The concept relies on the successive ligation of oligomers that contain minimal sequence motifs. It was applied here to the synthesis of digitally-encoded poly(triazole amide)s, in which propyl and 2-methyl propyl motifs are used to code 0 and 1, respectively. A library of four oligo(triazole amide)s containing the information dyads 00, 01, 10, and 11 was prepared. These oligomers contain two reactive functions, that is, an alkyne and a carboxylic acid. Thus, they can be linked to another with the help of a reactive spacer containing azide and amine functions. Using two successive chemoselective steps, that is, azide-alkyne Huisgen cycloaddition and carboxylic acid-amine coupling, monodisperse polymers can be obtained. In particular, the library of dyads permits the implementation of any desired sequence using a small number of steps. As a proof-of-concept, the synthesis of molecular bytes 00000000 and 00000110 is described.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据