期刊
ORGANIC LETTERS
卷 18, 期 20, 页码 5196-5199出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.6b02222
关键词
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资金
- National Natural Science Foundation of China [81273378, 21372261, 81673305]
- Jiangsu Province Funds for Distinguished Young Scientists [BK20160033]
- opening project of the State Key Laboratory of High Performance Ceramics and Superfine Microstructure [SKL201513SIC]
- Program for New Century Excellent Talents in University [NCET-13-1033]
A novel class of O-2-(2,4-dinitrophenyl)-1-[N,N-bis (2-substituted ethyl)amino]diazen-1-ium-1,2-diolates 4-6 were designed, synthesized, and biologically evaluated. The most active compound 6 caused significant DNA damage by releasing N,N-bis(2-TsO ethyl)amine and two molecules of nitric oxide (NO) after activation by GST/GSH in cancer cells, being more cytotoxic against three cancer cell lines than a well-known diazeniumdiolate-based anticancer agent JS-K, suggesting that the strategy has potential to extend to other O-2- deriveddiazeniumdiolates to improve anticancer activity.
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