期刊
ORGANIC LETTERS
卷 18, 期 14, 页码 3494-3497出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.6b01712
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资金
- Amgen Internship Program
Decarboxylative coupling of carboxylic acids with activated olefins has been accomplished using visible light photoredox catalysis. The strategic placement of a radical stabilizing aromatic group at the beta-position of the olefin component biases the regioselectivity of the addition, allowing reliable, facile access to anti-Michael-type products from readily available precursors. The scope of this methodology was demonstrated with a range of carboxylic acids and appropriately substituted olefins and was applied toward a two-step synthesis of the antiarrhythmic agent encainide.
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