期刊
ORGANIC LETTERS
卷 18, 期 15, 页码 3650-3653出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.6b01699
关键词
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资金
- Strategic Priority Research Program of the Chinese Academy of Sciences [XDA11030403]
- NSFC [41376155, 21172094, 21372100, 21502204, 31270402, 41476135]
- Guangzhou Science and Technology Project [201604010081]
- National High Technology Research and Development Program (863 Program) [2013AA092902]
- Guangzhou Branch of the Supercomputing Center of Chinese Academy of Sciences
Three dimeric nitrophenyl trans-epoxyamides, chrysamides A-C (1-3), were obtained from the deep-sea-derived fungus Penicillium chrysogenum SCSIO41001. Their structures were characterized by spectroscopic analysis, electronic circular dichroism computations, and X-ray single-crystal diffraction analysis. Notably, compound 1 possesses a novel centrosymmetric dimer skeleton featuring an unprecedented 7-oxa-2,5-diazabicyclo[2.2.1]heptane ring system, which represents the first example of dimeric nitrophenyl trans-epoxyamide in nature. Compound 3 suppresses the production of proinflammatory cytokine interleukin-17. A possible biosynthetic pathway of 1-3 was proposed.
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