4.8 Article

Ag2CO3/CA-AA-AmidPhos Multifunctional Catalysis in the Enantioselective 1,3-Dipolar Cycloaddition of Azomethine Ylides

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ORGANIC LETTERS
卷 18, 期 3, 页码 404-407

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AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.5b03430

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  1. National Natural Science Foundation of China [21202042]
  2. Hunan Provincial Natural Science Foundation of China [13JJ4090]

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The new Ag2CO3/CA-AA-amidphos complexes have been demonstrated as highly efficient multifunctional catalysts in the asymmetric 1,3-dipolar cycloaddition of azomethine ylides. Under optimal conditions, highly functionalized endo-4 pyrrolidines were obtained with excellent yields (up to 99% yield) and enantioselectivities (up to 96% ee).

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