期刊
ORGANIC LETTERS
卷 18, 期 10, 页码 2335-2338出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.6b00685
关键词
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资金
- Victoria S. and Bradley L. Geist Foundation [15ADVC-74420]
- ECD: Electronic Circular Dichroism
- US Department of Agriculture [58-6408-2-0009]
- ARS [813738, ARS-0428996] Funding Source: Federal RePORTER
Three unusual polyketide-sesquiterpene metabolites peyronellins A-C (1-3), along with the new epoxyphomalin analog 11-dehydroxy epoxyphomalin A (4), have been isolated from the endophytic fungus Peyronellaea coffeae-arabicae FT238, which was isolated from the native Hawaiian plant Pritchardia lowreyana. The structures of compounds 1-4 were characterized based on NMR and MS spectroscopic analysis. The absolute configuration (AC) of the compounds was determined by electronic circular dichroism (ECD). Compound 4 showed antiproliferative activity with an IC50 of 0.5 mu M against OVCAR3, and it also strongly inhibited Stat3 at 5 mu M.
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