4.8 Article

Rh(I)-Catalyzed Insertion of Allenes into C-C Bonds of Benzocyclobutenols

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ORGANIC LETTERS
卷 18, 期 2, 页码 328-331

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AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.5b03518

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  1. National Key Basic Research Program of China [2012CB224802]
  2. NSF of China [21371107]
  3. Tsinghua-Peking Joint Centers for Life Sciences

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Herein we report a Rh(I)-catalyzed two carbon insertion into C-C bonds of benzocyclobutenols by employing symmetrical and unsymmetrical allenes. This reaction provides rapid access to alkylidene tetralins bearing two adjacent stereogenic centers in good yields and diasteroselectivities.

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