期刊
ORGANIC LETTERS
卷 18, 期 15, 页码 3686-3689出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.6b01733
关键词
-
资金
- JST (ACT-C: Advanced Catalytic Transformation program for Carbon utilization)
- JSPS KAKENHI [26620078]
- Grants-in-Aid for Scientific Research [26620078] Funding Source: KAKEN
The combination of difluoroiodomethane and zinc dust or diethylzinc can readily lead to (difluoromethyOzinc reagents. Therefore, the first copper-catalyzed difluoromethylation of aryl iodides with the zinc reagents is accomplished to afford the difluoromethylated arenes. The reaction proceeds efficiently through the ligand/activator-free operation without addition of ligands for copper catalyst (e.g., phen and bpy) and activators for zinc reagent (e.g., KF, CsF, and NaO-t-Bu). Moreover, transmetalation of the CF2H group from zinc reagent to copper catalyst proceeds even at room temperature to form the cuprate [Cu(CF2H)(2)](-).
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据