期刊
ORGANIC LETTERS
卷 18, 期 10, 页码 2399-2402出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.6b00883
关键词
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资金
- JSPS KAKENHI [15K14718]
- Grants-in-Aid for Scientific Research [15K14718] Funding Source: KAKEN
An expeditious enantioselective total synthesis of amphirionin-4, a remarkably potent promoter of the proliferation of ST-2 cells, has been achieved from (+/-)-(E)-1,4-hexadien-3-ol by an 8-pot sequence that features the Sharpless kinetic resolution, iodoetherification, and the CBS reduction to install the stereocenters, utilization of four one pot transformations to streamline the synthetic process, and the Stille coupling reaction at nearly the center of the target molecule to complete the total synthesis.
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