期刊
ORGANIC LETTERS
卷 19, 期 1, 页码 110-113出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.6b03385
关键词
-
资金
- National Key Research and Development Program [2016YFA0202900]
- National Natural Science Foundation of China [21125210, 21421091]
A new method for the synthesis of delta- and alpha carbolines through Ni-catalyzed [2 + 2 + 2] cycloaddition of ynamide-nitriles or alkyne-cyanamides with alkynes has been developed. The catalytic system of NiCl2(DME)/dppp/Zn with a low-cost Ni(II)-precursor was first utilized in Ni-catalyzed [2 + 2 + 2] cycloaddition reactions, and the in situ generated Lewis acid may play an important role for the successful transformation. Not only internal alkynes but also terminal alkynes undergo the desired cycloaddition reactions efficiently to furnish the carboline derivatives with wide diversity and functional group tolerance.
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