期刊
ORGANIC LETTERS
卷 18, 期 5, 页码 1170-1173出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.6b00293
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资金
- Danish Agency for Science, Technology and Innovation
- H. Lundbeck A/S
A practical diastereodivergent access to beta-fluoropyrrolidines with two adjacent stereocenters has been demonstrated, by either enhancing or completely reversing the substrate control, in the diastereoselective fluorination of a series of diverse pyrrolidinyl carbaldehydes using organocatalysis. Furthermore, enamine catalysis has been successfully utilized for kinetic resolution, obtaining a fluorinated beta-prolinol analogue with two adjacent tetrasubstituted chiral centers in 95% ee from a racemic substrate.
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