期刊
ORGANIC & BIOMOLECULAR CHEMISTRY
卷 14, 期 24, 页码 5511-5515出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c5ob02580j
关键词
-
资金
- Nankai University
- Pennsylvania State University
An efficient protocol for palladium-catalyzed beta-C(sp(3))-H arylation of aliphatic carboxamides equipped with a 2-(2-pyridyl) ethylamine (PE) auxiliary was developed. The PE auxiliary is uniquely effective at facilitating the arylation of primary C(sp(3))-H bonds with sterically hindered aryl iodides. A variety of aryl iodides bearing alkoxyl, carbonyl, nitro and halogen groups on the ortho position can react with the PE-coupled phthaloyl alanine substrate in moderate to excellent yield. These reactions offer a useful solution for preparing complex beta-aryl alpha-amino acid products from readily accessible starting materials.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据