期刊
ORGANIC & BIOMOLECULAR CHEMISTRY
卷 14, 期 45, 页码 10723-10732出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c6ob02037b
关键词
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资金
- Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD)
- NSFC [21302015, 21272165]
- Jiangsu Planned Projects for Postdoctoral Research Fund [1501094B]
- China Postdoctoral Science Foundation
A novel in situ generation of nitrilium from a nitrile ylide and the subsequent Mumm rearrangement of carboxylic acid, nitrile, and diazo compounds gave various unsymmetrical diacylglycine esters in moderate to high yields. This copper-catalyzed cascade reaction enables one-pot generation of two C-N bonds, one C=O bond, and one C-H bond, with nitrogen as the only byproduct. The reaction has a broad functional-group tolerance, is rapid, easily scales up to the 100 mmol scale, and is insensitive to air and moisture.
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